Economical Test Methods for Developmental Neurobehavioral Toxicity
نویسندگان
چکیده
منابع مشابه
Economical test methods for developmental neurobehavioral toxicity.
The assessment of behavioral changes produced by prenatal or early postnatal exposure to potentially noxious agents requires both the designing of ad hoc tests and the adaptation of tests for adult animals to the characteristics of successive developmental stages. The experience in designing tests is still more limited than in the adaptation of tests, but several tests have already proven their...
متن کاملNeurobehavioral aspects of developmental toxicity testing.
Tests for detection of neurobehavioral changes in the offspring have been a regulatory requirement in developmental toxicity testing of drugs for almost 20 years. Keeping their purpose of hazard identification and risk assessment for humans in mind, investigators and agency reviewers have become deeply ingrained with some stereotyped behaviors with respect to such relevant issues as choice of a...
متن کاملRisk Assessment for Neurobehavioral Toxicity
Background: Brain activity has been investigated by several methods with different principles, notably optical ones. Each method may offer information on distinct physiological or pathological aspects of brain function. The ideal instrument to measure brain activity should include complementary techniques and integrate the resultant information. As a "low cost" approach towards this objective, ...
متن کاملRisk assessment for neurobehavioral toxicity.
A study by the National Academy of Sciences/National Research Council (NAS/NRC) found neurobehavioral toxicity to be one of the areas where almost no data are available for the assessment of toxicity. Using the NAS/NRC report and a data base from the American Conference of Government Industrial Hygienists (ACGIH), an estimate of the number of neurobehavioral toxins in commercial chemicals can b...
متن کاملChapter 6 – NEUROBEHAVIORAL TOXICITY ASSESSMENTS
Testing must characterize cognitive lapses and mood changes in healthy individuals faced with relevant operational stressors, including chemical exposures and interactions with other stressors, and should be based on understanding effects of final common pathways in brain physiology (e.g. hypoor hyperglycemia, and hypoxia, oxidative stress, and inflammation). Stressors may affect a common hiera...
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ژورنال
عنوان ژورنال: Environmental Health Perspectives
سال: 1996
ISSN: 0091-6765
DOI: 10.2307/3432648